Downstream processing (DSP) of monoclonal antibodies (mAbs) requires an efficient purification process to achieve high product purity.
The most important aspect of mAb purification is the capture step, usually performed with a Protein A chromatography resin, since this alone can achieve >95% purity. To successfully support biopharmaceutical manufacturing, Protein A resins must offer exceptional performance.
TOYOPEARL Super A, the next-generation Protein A chromatography resin from Tosoh Bioscience, is:
- Super Efficient: The dynamic binding capacity (DBC) of TOYOPEARL Super A resin exceeds 70 mg mAb/mL resin, which optimizes productivity.
- Super Robust: Alkaline stability prolongs the lifetime of TOYOPEARL Super A resin, even in rigorous cleaning conditions.
- Super Flexible: Mild elution pH conditions protect your antibody’s structural integrity and minimize aggregation.
- Super Effective: Achieve >95% reduction in host cell protein (HCP), thereby streamlining subsequent DSP.
Product Overview
Application Note
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