Oligonucleotide therapeutics are rapidly gaining traction as powerful tools for treating a wide range of diseases, with DMT-protected oligos playing a vital role in their efficient synthesis and processing.
Tosoh Bioscience recently developed a novel hydrophobic interaction chromatography (HIC) resin, TSKgel Phenyl-3PW (20), offering improved selectivity and performance for oligo purification, while being a sustainable alternative to reversed phase chromatography.
The table below shows the improvements made for binding capacity, in comparison to an already existing HIC resin by Tosoh with identical ligand.
| Property | Toyopearl Phenyl-650M | TSKgel Phenyl-3PW (20) (Novel Resin) |
|---|---|---|
| Base Material | Polymethacrylate | |
| Average Bead Size | 65 µm | 20 µm |
| Average Pore Size | 100 nm | 25 nm |
| Binding Capacity* | 9 mg/mL | 25 mg/mL |
| Binding Capacity** | 11 mg/mL | 45 mg/mL |
* 1.0 mol/L (NH4)2SO4 @ 4 min residence time
** 1.5 mol/L (NH4)2SO4 @ 4 min residence time
For more information on our products visit our websites:
| In the EMEA | In the Americas |