What is Multi-Column Chromatography (MCC)? The Next Step in Efficient Bioprocessing
MCC = Multi-Column Chromatography.
MCC uses multiple smaller columns instead of one large column.
- MCC delivers unmatched productivity gains.
MCC provides powerful benefits to you
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Enhanced Resin Utilization
Batch: Utilizes a single large column, underutilizing resin capacity as the entire column must accommodate the feed, resulting in significant resin wastage.
MCC: Employs smaller columns that operate sequentially. Resin capacity is maximized as columns are loaded to their full potential, reducing resin need by up to 90%. -
Reduced Buffer Consumption
Batch: Operating a large column through each process phase requires high buffer volumes.
MCC: Optimized resin utilization results in up to 40 % lower buffer demand. -
Shorter Processing Times
Batch: Runs with low flow rates and requires sequential steps, leading to idle periods during column re-equilibration.
MCC: Operates columns at high flow rates in parallel, allowing simultaneous loading, separation, elution, and regeneration, drastically reducing processing times. -
Increased Productivity
Batch: Limited by the size and capacity of a single column, resulting in a linear relationship between scale and productivity.
MCC: By distributing the workload across multiple smaller columns, MCC achieves a huge increase in productivity, enabling higher throughput without larger equipment investments. -
Reduced Costs
MCC allows considerable cost savings due to lower solvent and resin requirements, and shorter processing times.
Want to Discuss Your Needs?
At Tosoh, we offer comprehensive support to ensure your success with MCC. Our expert team is here to guide you through every step of the process.
How Tosoh Supports Your Transition to MCC
We understand the challenges of adopting new technologies and are dedicated to making the transition to MCC as smooth as possible.
Our MCC Solutions:
- Octave™ BIO and PRO Systems: Designed for seamless scalability, these systems support both process development and GMP-compliant manufacturing. Their flexible architecture accommodates up to eight columns.
- SkillPak™ Pre-Packed Columns: Pre-packed with TOYOPEARL™ or TSKgel™ resins, these columns are optimized for MCC, providing superior performance for both development and large-scale production.
PROComposer Software: Our unified PROComposer method-generating software facilitates method development and quick transition from batch to MCC, ensuring precision and efficiency at every process step.
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1
Process Consultation
Tosoh experts work closely with clients to evaluate workflows and design tailored MCC solutions.
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2
Training and Workshops
Hands-on training and educational resources to confidently operate MCC systems.
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3
Seamless Integration
Tosoh’s team assists with the transition from batch to MCC, including process optimization and scale-up strategies.
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4
Installation and IQ/OQ support
Guidance on compliance with regulatory standards, including FDA manufacturing practices.